I think twitter knows everbody. As you know, twitter is very fast and you will be flooded with information.
1.) Do people in lists. Work with these lists.
2.) Be funny, and always post something with an picture.
3.) Check this out: Put in the search field: my clock is broken. If you are selling clocks, i think it´s time to start a conversation. Now, check your niche.
4.) Engage where ever you can. Ask, give advise etc.
5.) Follow people in your niche. Some will follow you back, it´s just around 10%, but that´s ok.
6.) Look what´s trending, example: MotivationMonday. Be prepared and post a funny think in the timeline.
7.) Always use hashtags.
8.) More Tweets = more followers.